Benzinga | Oct 26, 2021 08:07AM EDT

AstraZeneca's Imfinzi/Chemo Combo Strikes First Immunotherapy Wins In Bile Duct Cancer Trial

* AstraZeneca Plc (NASDAQ:AZN) revealed topline results from the Phase 3 TOPAZ-1 study.

* Related: AstraZeneca Touts Longest Survival Update In Lung Cancer Setting With Imfinzi/Chemo Data.

* According to the data, a combo of Imfinzi (durvalumab) and chemotherapy significantly extended the lives of first-line patients with advanced biliary tract cancer over chemo alone.

* The details are slim, but AstraZeneca said its combo achieved its overall survival and progression-free survival endpoints and a key overall response rate secondary endpoint.

* The readout came from an interim analysis of the trial. It marked the first time an immuno-oncology regimen beat standard of care in a randomized trial for front-line biliary tract cancer.

* This rare gastrointestinal cancer reports about 50,000 new diagnoses each year across the U.S., Europe, and Japan.

* Price Action: AZN shares are up 0.39% at $62.01 during the premarket session on the last check Tuesday.