Benzinga | May 13, 2021 08:37AM EDT

AcelRx Pharma Highlights Poster Presentation At Regional Anesthesiology and Acute Pain Medicine Meeting To Review Results Of Study On Intraoperative Admin. Of DSUVIA 30 mcg For Mgmt. Of Acute Pain

AcelRx Pharmaceuticals, Inc. (NASDAQ:ACRX), (AcelRx), a specialty pharmaceutical company focused on the development and commercialization of innovative therapies for use in a medically supervised setting, today announced a poster presentation at the 46th Annual Regional Anesthesiology and Acute Pain Medicine Meeting reviewing the results of a study on the intraoperative administration of DSUVIA (sufentanil sublingual tablet; SST) 30 mcg for the management of acute pain in an ambulatory surgery center. The primary objective of this study was to determine if SST 30 mcg given prior to emergence from anesthesia was efficacious in reducing initial post anesthesia care unit (PACU) pain scores compared to a control group. Secondary outcomes included opioid use and percentage of patients opioid free in PACU, and time until ready to discharge.

The study was a prospective, randomized, controlled trial conducted at an ambulatory surgery center with patients aged 18-80 undergoing orthopedic surgery under general anesthesia. A total of 50 patients were included in the final analysis. There were no significant differences in baseline characteristics or duration of surgery between the two groups. The pain score on arrival to PACU was not significantly different between either group. However, patients in the SST group required 50% less opioids in the PACU (p=0.018), with significantly more of them opioid-free (36% vs 8%; p=0.037). Furthermore, SST-treated patients had improved overall benefit of analgesia scores (OBAS) compared to the control group (p=0.006). OBAS is a validated 7-item tool that assesses pain intensity, adverse effects and patients' satisfaction with analgesia.

The authors concluded that while SST 30 mcg administered intraoperatively did not affect patients' pain scores on arrival to PACU, patients that received SST did show improvement in PACU opioid requirements and OBAS scores, with more of them opioid-free in the PACU. The authors stated that the most compelling result of this study was the significant difference in OBAS and percent of opioid-free patients in the SST group, reflecting greater patient satisfaction with SST, which is more meaningful than a single pain score assessed at any given point in time. Objectively, the higher patient satisfaction was supported by the significantly lower rescue opioid requirement observed in the SST group. Limitations of the study include that the SST was not compared to an active comparator, in that it did not allow for preemptive opioid analgesia in the control group. Also, as the data collection ended at discharge, the authors were unable to assess any additional analgesic benefit of SST beyond the immediate postoperative period.

Details of the presentation and the link to the poster is as follows: https://epostersonline.com/ASRASPRING21/node/694?view=true

Title: Intraoperative sublingual sufentanil for acute pain in the ambulatory surgery center

Date & Time: Thursday, May 13, 2021; 10:30am-12:00pm ET

Location: Disney's Yacht & Beach Club, Lake Buena Vista, FL

Presenter: Justin A. Mottaghi, MD

One of the investigators of the study is a paid consultant for AcelRx but was not compensated for this study.